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1

Synthesis of [5-14C]-1,1,12,12-tetraethoxy-4,9-diazadodecane dinitrate

Vijayalakshmi V. Somayaji, Tse W. Hall, Leonard I. Wiebe, Edward E. Knaus, James P. Demers

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1989

Langue:

english

Fichier:

PDF, 269 KB

english, 1989

2

Radionuclides, radiotracers and radiopharmaceuticals for in vivo diagnosis

Leonard I. Wiebe

Journal:

Radiation Physics and Chemistry (1977)

Année:

1977

Langue:

english

Fichier:

PDF, 568 KB

english, 1977

3

[99mTc]Technetium labelled PnAo-azomycin glucuronides: a novel class of imaging markers of tissue hypoxia

Piyush Kumar, Leonard I. Wiebe, Rezaul H. Mannan, Zaihui Zhang, Haiyan Xia, Alexander J.B. McEwan

Journal:

Applied Radiation and Isotopes

Année:

2002

Langue:

english

Fichier:

PDF, 149 KB

english, 2002

4

Corrigendum to: “[99mTc] technetium labelled PnAo-azomycin glucuronides: a novel class of imaging markers of tissue hypoxia” [Applied Radiation and Isotopes 57 (2002) 719–728]

Piyush Kumar, Leonard I. Wiebe, Rezaul H. Mannan, Zaihui Zhang, Haiyan Xia, Alexander J.B. Mc Ewan

Journal:

Applied Radiation and Isotopes

Année:

2003

Langue:

english

Fichier:

PDF, 44 KB

english, 2003

5

Synthesis and properties of 5-(1,2-dihaloethyl)-2′-deoxyuridines and related analogues

Rakesh Kumar, Edward E. Knaus, Leonard I. Wiebe

Journal:

Journal of Heterocyclic Chemistry

Année:

1991

Fichier:

PDF, 708 KB

1991

6

Pharmacokinetics and Tissue Distribution of (±)-3′-Azido-2′,3′-dideoxy-5′-O-(2-bromomyristoyl)thymidine, a Prodrug of 3′-Azido-2′,3′-dideoxythymidine (AZT) in Mice

Keykavous Parang, Leonard I. Wiebe, Edward E. Knaus

Journal:

Journal of Pharmacy and Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 732 KB

english, 1998

7

The King–Devick test and sports-related concussion: Study of a rapid visual screening tool in a collegiate cohort

Kristin M. Galetta, Lauren E. Brandes, Karl Maki, Mark S. Dziemianowicz, Eric Laudano, Megan Allen, Kathy Lawler, Brian Sennett, Douglas Wiebe, Steve Devick, Leonard V. Messner, Steven L. Galetta, Lau

Journal:

Journal of the Neurological Sciences

Année:

2011

Langue:

english

Fichier:

PDF, 339 KB

english, 2011

8

New [11C]Phosgene Based Synthesis of [11C]Pyrimidines for Positron Emission Tomography

Seki, Koh-ichi, Ohkura, Kazue, Sanoki, Kimihito, Nishijima, Ken-ichi, Tamaki, Nagara, Kuge, Yuji, I. Wiebe, Leonard, Takahashi, Masayuki, Akizawa, Hiromichi

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 328 KB

english, 2009

9

Targeted Delivery of Macromolecular Drugs: Asialoglycoprotein Receptor (ASGPR) Expression by Selected Hepatoma Cell Lines used in Antiviral Drug Development

Li, Yan, Huang, Guifang, Diakur, James, Wiebe, Leonard

Journal:

Current Drug Delivery

Année:

2008

Langue:

english

Fichier:

PDF, 231 KB

english, 2008

10

Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia

Elsaidi, Hassan, Ahmadi, Fatemeh, Wiebe, Leonard, Kumar, Piyush

Journal:

Pharmaceuticals

Année:

2019

Langue:

english

Fichier:

PDF, 2.60 MB

english, 2019

11

Syntheses of [2-2H]-5-ethynyl-1-(β-D-ribofuranosyl)imidazole-4-carboxamide and 5-ethynyl-1-([5-3H]-β-D-ribofuranosyl)imidazole-4-carboxamide (EICAR)

Noriaki Minakawa, Akira Matsuda, Zuping Xia, Leonard I. Wiebe, Edward E. Knaus

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1996

Langue:

english

Fichier:

PDF, 654 KB

english, 1996

12

Synthesis and radioiodination of 3-(E)-(2-iodovinyl)-N-acetyl-4-cysteaminylphenol, a putative tyrosinase substrate for imaging neural crest tumours

Shradha Singh, Kowichi Jimbow, Piyush Kumar, Alexander J. McEwan, Leonard I. Wiebe

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1998

Fichier:

PDF, 332 KB

1998

13

Synthesis and Biological Evaluation of Butanoate, Retinoate, and Bis(2,2,2-trichloroethyl)phosphate Derivatives of 5-Fluoro-2′-deoxyuridine and 2′,5-Difluoro-2′-deoxyuridine as Potential Dual Action Anticancer Prodrugs

Zuping Xia, Leonard I. Wiebe, Gerald G. Miller, Edward E. Knaus

Journal:

Archiv der Pharmazie

Année:

1999

Langue:

english

Fichier:

PDF, 126 KB

english, 1999

14

The relationship between magnetic resonance diffusion imaging and autoradiographic markers of cerebral blood flow and hypoxia in an animal stroke model

Mark F. Lythgoe, Stephen R. Williams, Albert L. Busza, Leonard Wiebe, Alexander J.B. McEwan, David G. Gadian, Isky Gordon

Journal:

Magnetic Resonance in Medicine

Année:

1999

Langue:

english

Fichier:

PDF, 322 KB

english, 1999

15

Synthesis and Antifungal Activities of Myristic Acid Analogs

Keykavous Parang, Edward E. Knaus, Leonard I. Wiebe, Soroush Sardari, Mohsen Daneshtalab, Ferenc Csizmadia

Journal:

Archiv der Pharmazie

Année:

1996

Langue:

english

Fichier:

PDF, 922 KB

english, 1996

16

Synthesis and Antiviral Activity of 5-Ethyl-5-halo-6-alkoxy-(or Azido)-5,6-dihydro-2′-deoxyuridine Diastereomers as Potential Prodrugs to 5-Ethyl-2′-deoxyuridine

Rakesh Kumar, Leonard I. Wiebe, Edward E. Knaus

Journal:

Archiv der Pharmazie

Année:

1997

Langue:

english

Fichier:

PDF, 474 KB

english, 1997

17

Pharmacokinetics and metabolism of the novel synthetic C-nucleoside, 1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluoro- 5-iodobenzene: a potential mimic of 5-iodo-2′-deoxyuridine

Panteha Khalili, Ebrahim Naimi, Edward E. Knaus, Leonard I. Wiebe

Journal:

Biopharmaceutics & Drug Disposition

Année:

2002

Langue:

english

Fichier:

PDF, 106 KB

english, 2002

18

Dose-dependent pharmacokinetics of 1-(2-Deoxy-β-D- ribofuranosyl)-2,4-difluoro-5-iodobenzene: A potential mimic of 5-iodo-2′-deoxyuridine

Panteha Khalili, Ebrahim Naimi, Wei Yan Sun, Edward E. Knaus, Leonard I. Wiebe

Journal:

Biopharmaceutics & Drug Disposition

Année:

2003

Langue:

english

Fichier:

PDF, 150 KB

english, 2003

19

ChemInform Abstract: Synthesis and Biological Evaluation of Butanoate, Retinoate, and Bis(2,2,2-trichloroethyl)phosphate Derivatives of 5-Fluoro-2′-deoxyuridine and 2′,5-Difluoro-2′-deoxyuridine as Potential Dual Action Anticancer Prodrugs.

Zuping Xia, Leonard I. Wiebe, Gerald G. Miller, Edward E. Knaus

Journal:

Année:

1999

Fichier:

PDF, 26 KB

1999

20

ChemInform Abstract: Synthesis of Iodoaminoimidazole Arabinoside (IAIA): A Potential Reductive Metabolite of the Spect Imaging Agent, Iodoazomycin Arabinoside (IAZA).

Herbert C. Lee, Piyush Kumar, Leonard I. Wiebe, Robert McDonald, John R. Mercer, Kazue Ohkura, Koh-ichi Seki

Journal:

Année:

2000

Fichier:

PDF, 28 KB

2000

21

ChemInform Abstract: Syntheses of 4-[1-(2-Deoxy-β-D-ribofuranosyl)] Derivatives of 2-Substituted-5-fluoroaniline: “Cytosine Replacement” Analogues of Deoxycytidine for Evaluation as Anticancer and antihuman Immunodeficiency Virus (anti-HIV) Agents.

Zhi-Xian Wang, Leonard I. Wiebe, Erik De Clercq, Jan Balzarini, Edward E. Knaus

Journal:

Année:

2000

Fichier:

PDF, 34 KB

2000

22

ChemInform Abstract: An Improved Synthesis of α-AZA, α-AZP and αAZG, the Precursors to Clinical Markers of Tissue Hypoxia.

Piyush Kumar, Leonard I. Wiebe, Elena Atrazheva, Manju Tandon

Journal:

Année:

2001

Fichier:

PDF, 31 KB

2001

23

ChemInform Abstract: Synthesis of 1-(2-Deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: “Thymine Replacement” Analogues of Thymidine for Evaluation as Anticancer and Antiviral Agents.

Zhi-Xian Wang, Weili Duan, Leonard I. Wiebe, Jan Balzarini, Erik De Clercq, Edward E. Knaus

Journal:

Année:

2001

Fichier:

PDF, 37 KB

2001

24

ChemInform Abstract: Synthesis of 1-(2-Deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzene Thymidine Mimics, Some Related α-Anomers, and Their Evaluation as Antiviral and Anticancer Agents.

Zhi-Xian Wang, Weili Duan, Leonard I. Wiebe, Jan Balzarini, Erik De Clercq, Edward E. Knaus

Journal:

Année:

2001

Fichier:

PDF, 37 KB

2001

25

ChemInform Abstract: Synthesis of Unnatural 7-Substituted-1-(2-deoxy-β-D-ribofuranosyl)isocarbostyrils: “Thymine Replacement” Analogues of Deoxythymidine for Evaluation as Antiviral and Anticancer Agents.

Ebrahim Naimi, Weili Duan, Leonard I. Wiebe, Edward E. Knaus

Journal:

Année:

2002

Fichier:

PDF, 41 KB

2002

26

ChemInform Abstract: Synthesis of 1-[(2-Hydroxyethoxy)methyl]- and 1-[(1,3-Dihydroxy-2-propoxy)methyl]- Derivatives of 5-Substituted-2,4-difluorobenzene: Unnatural Acyclo Thymidine Mimics for Evaluation as Anticancer and Antiviral Agents.

Zhi-Xian Wang, Weili Duan, Leonard I. Wiebe, Erik De Clercq, Jan Balzarini, Edward E. Knaus

Journal:

Année:

2002

Fichier:

PDF, 33 KB

2002

27

Synthesis of 1-β-D-(5-Deoxy-5-iodoarabinofuranosyl)-2-nitroimidazole (β-IAZA): A Novel Marker of Tissue Hypoxia.

Piyush Kumar, Kazue Ohkura, Davood Beiki, Leonard Irving Wiebe, Koh-ichi Seki

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 151 KB

english, 2003

28

cycloSaligenyl Pronucleotides of 5-Iodo and 5-Trifluoromethyl-1- (2-deoxy-β-D-ribofuranosyl)-2,4-difluorobenzene Mimics of Thymidine: Synthesis and Evaluation of This Pronucleotide Monophosphate Delivery System for Compounds with Potential Anticancer Activity.

Wei Yan Sun, Aihua Zhou, Leonard I. Wiebe, Edward E. Knaus

Journal:

Année:

2004

Fichier:

PDF, 95 KB

2004

29

Synthesis and Antiviral Activity of Novel Fluorinated 2′,3′-Dideoxynucleosides.

Piyush Kumar, Kazue Ohkura, Jan Balzarini, Erik De Clercq, Koh-ichi Seki, Leonard I. Wiebe

Journal:

Année:

2004

Fichier:

PDF, 184 KB

2004

30

A One-Pot Synthesis of 1-α- and 1-β-D-Arabinofuranosyl-2-nitroimidazoles: Synthons to the Markers of Tumor Hypoxia.

Ebrahim Naimi, Piyush Kumar, Alexander J. B. McEwan, Leonard I. Wiebe

Journal:

Année:

2005

Fichier:

PDF, 23 KB

2005

31

Synthesis of 1-(2-deoxy-β-D-ribofuranosyl)-2,4- difluoro-5-(2-halo-1-hydroxyethyl)benzenes and related derivatives: “thymine replacement” analogs of deoxythymidine for evaluation as antiviral and anticancer agents

Ebrahim Naimi, Leonard I. Wiebe, Jan Balzarini, Erik De Clercq, Edward E. Knaus

Journal:

Drug Development Research

Année:

2001

Langue:

english

Fichier:

PDF, 174 KB

english, 2001

32

Synthesis of 5-(1-azido-2-haloethyl)arabinouridines

Rakesh Kumar, Leonard I. Wiebe, Edward E. Knaus

Journal:

Journal of Heterocyclic Chemistry

Année:

1997

Fichier:

PDF, 152 KB

1997

33

18F-FESB: synthesis and automated radiofluorination of a novel 18F-labeled pet tracer for β-amyloid plaques

Piyush Kumar, Weizhong Zheng, Stephen A. McQuarrie, Jack H. Jhamandas, Leonard I. Wiebe

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2005

Langue:

english

Fichier:

PDF, 236 KB

english, 2005

34

Synthesis of [2-14C]-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro(chloro)uracil

Hemant K. Misra, Leonard I. Wiebe, Edward E. Knaus

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1987

Langue:

english

Fichier:

PDF, 422 KB

english, 1987

35

An improved synthesis of [1-14C]-labelled 2-butynedioic acid, succinic acid and succinyl chloride

Vijayalakshmi V. Somayaji, Tse W. Hall, Leonard I. Wiebe, Edward E. Knaus

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1988

Langue:

english

Fichier:

PDF, 236 KB

english, 1988

36

An efficient, high specific activity radioiodination of 5-(1-hydroxy/methoxy-2-iodoethyl)-2′-deoxyuridine by isotope exchange labelling in pivalic acid melt

Takashi Iwashina, Rakesh Kumar, Edward E. Knaus, Leonard I. Wiebe

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1990

Langue:

english

Fichier:

PDF, 315 KB

english, 1990

37

Effect of acyclovir on the uptake of 131 I-labelled 1-(2′fluoro-2′-deoxy-βD-D-arabinofuranosyl)-5-lodouracil in herpes infected cells

Dorothy R. Tovell, Harold P. Yacyshyn, Hemant K. Misra, Edward E. Knaus, Leonard I. Wiebe, John Samuel, M. John Gill, D. Lorne J. Tyrrell

Journal:

Journal of Medical Virology

Année:

1987

Langue:

english

Fichier:

PDF, 322 KB

english, 1987

38

Synthesis of brain-targeted 1-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-(E)-5-(2-iodovinyl)uracil coupled to a dihydropyridine ⇋ pyridinium salt redox chemical-delivery system

Kevin W. Morin, Leonard I. Wiebe, Edward E. Knaus

Journal:

Carbohydrate Research

Année:

1993

Langue:

english

Fichier:

PDF, 615 KB

english, 1993

39

Čerenkov counting and Čerenkov-scintillation counting with high refractive index organic liquids using a liquid scintillation counter

Leonard I. Wiebe, F. Helus, W. Maier-Borst

Journal:

The International Journal of Applied Radiation and Isotopes

Année:

1978

Langue:

english

Fichier:

PDF, 388 KB

english, 1978

40

Some performance characteristics of modern liquid scintillation counters

Stephen A. Mcquarrie, Christopher Ediss, Leonard I. Wiebe

Journal:

The International Journal of Applied Radiation and Isotopes

Année:

1983

Langue:

english

Fichier:

PDF, 309 KB

english, 1983

41

Synthesis of 131I, 125I and 82Br labelled (E)-5-(2-Halovinyl)-2′-deoxyuridines

John Samuel, Edward E. Knaus, Leonard I. Wiebe, D. Lorne Tyrrell

Journal:

The International Journal of Applied Radiation and Isotopes

Année:

1984

Langue:

english

Fichier:

PDF, 325 KB

english, 1984

42

Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models: VI. 1-(3′-[36Cl]-chloro-, 1-(3′-[82Br]-bromo- and 1-(3′-[123I]-iodo-3′-deoxy-β-D-arabinofuranosyl)uracil

Yip W. Lee, John R. Mercer, Leonard I. Wiebe, Edward E. Knaus

Journal:

The International Journal of Applied Radiation and Isotopes

Année:

1984

Langue:

english

Fichier:

PDF, 370 KB

english, 1984

43

Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models: VII. [2-14C]-5-ethyl-1-(2′-deoxy-β-D-ribofuranosyl)uracil

Yip W. Lee, Jerzy B. Giziewicz, Edward E. Knaus, Leonard I. Wiebe

Journal:

The International Journal of Applied Radiation and Isotopes

Année:

1984

Langue:

english

Fichier:

PDF, 267 KB

english, 1984

44

Synthesis of [6-36Cl]chlorouracil, [6-82Br]bromouracil and [6-123I]iodouracil

Douglas N. Abrams, Y.W. Lee, Edward E. Knaus, Leonard I. Wiebe

Journal:

The International Journal of Applied Radiation and Isotopes

Année:

1984

Langue:

english

Fichier:

PDF, 475 KB

english, 1984

45

The use of 113Sn/113mIn and 207Bi on solid supports as internal standards for energy calibration of a liquid scintillation counter

Leonard I. Wiebe, Christopher Ediss, Stephen A. McQuarrie

Journal:

The International Journal of Applied Radiation and Isotopes

Année:

1985

Langue:

english

Fichier:

PDF, 157 KB

english, 1985

46

The synthesis of radiolabelled 1-(2′-Fluoro-2′-deoxy-β-D-ribofuranosyl)-uracil and 1-(2′-chloro-2′-deoxy-β-D-ribofuranosyl)uracil

Douglas N. Abrams, John R. Mercer, Edward E. Knaus, Leonard I. Wiebe

Journal:

The International Journal of Applied Radiation and Isotopes

Année:

1985

Langue:

english

Fichier:

PDF, 680 KB

english, 1985

47

Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models—VIII. Synthesis and tissue distribution of N-[2-(hydroxyethoxy) methyl]-5-[3H]methyluracil

Yip W. Lee, Takashi Iwashina, Wendy P. Gati, Edward E. Knaus, Leonard I. Wiebe

Journal:

The International Journal of Applied Radiation and Isotopes

Année:

1985

Langue:

english

Fichier:

PDF, 349 KB

english, 1985

48

Asialoglycoprotein receptor-targeted superparamagnetic iron oxide nanoparticles

Guifang Huang, James Diakur, Zhenghe Xu, Leonard I. Wiebe

Journal:

International Journal of Pharmaceutics

Année:

2008

Langue:

english

Fichier:

PDF, 656 KB

english, 2008

49

Confocal laser scanning microscopy (CLSM) based evidence for cell permeation by mono-4-(N-6-deoxy-6-amino-β-cyclodextrin)-7-nitrobenzofuran (NBD-β-CyD)

Hai Wei, Weizhong Zheng, James Diakur, Leonard I. Wiebe

Journal:

International Journal of Pharmaceutics

Année:

2011

Langue:

english

Fichier:

PDF, 599 KB

english, 2011

50

An improved synthesis of 14C-labelled 2,2′-anhydrouridine, 2′-deoxyuridine and 5-ethyl-2′-deoxyuridine

John R. Mercer, Edward E. Knaus, Leonard I. Wiebe

Journal:

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes

Année:

1986

Langue:

english

Fichier:

PDF, 734 KB

english, 1986